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Bio Medical Sciences
Global Journal of Clinical Trials
DOI: 10.68438
Continuous / Open Access
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Research Article
Open Access
Year: 2026
Recombinant Human IL-22 Delivered in Polydopamine Nanoparticle for Inflammatory Bowel Disease and Schizophrenia
Adonis Sfera, MD*, Nyla Jafri, Melissa Mora, Jacob J Anton, Grace Ikhimiukor
Abstract:
Background: Emil Kraepelin believed that dementia praecox, the disorder we now call schizophrenia, was the result of brain poisoning with toxins generated in other parts of the body, especially the mouth, intestine, or genitals (1). In this regard, Kraepelin hinted at the microbiome and believed that microbial molecules could drive the pathogenesis of severe psychiatric illness. However, the infectious model of schizophrenia drew limited attention until the launching of Human Microbiome Project and the discovery of innate lymphoid cells (ILCs).