OA
Peer-Reviewed Journal
Open Access (CC BY 4.0)
Bio Medical Sciences
Archives of Clinical Case Reports and Reviews
ISSN: 3144-0037
DOI: 10.68438
Continuous / Open Access
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Case Study
Open Access
Year: 2026
Refractory psoriasis following long-term corticosteroid withdrawal and in- adequate response to cyclosporine: a case report
V. Sreshta, K. Meghana, V. Mahender
Abstract:
Psoriasis is a chronic immune-mediated skin disorder characterized by erythematous, scaly plaques. We report a case of a 53-year-old male with a 12-year history of psoriasis and diabetes mellitus who presented with severe exacerbation following long-term corticosteroid use and subsequent cyclosporine therapy. The patient developed high-grade fever, widespread erythematous rashes with peeling, and severe itching, along with abnormal hematological findings. Initial management with cyclosporine and topical corticosteroids provided limited benefit, and abrupt withdrawal of prednisolone triggered a rebound flare due to a surge in pro-inflammatory cytokines. Cyclosporine therapy further led to paradoxical worsening of psoriasis, likely due to suboptimal response. The patient was subsequently initiated on ixekizumab, an IL-17A inhibitor, which demonstrated significant clinical improvement and near-resolution of psoriatic lesions. This case emphasizes the challenges in managing severe psoriasis in patients with prolonged corticosteroid exposure and highlights the role of biologic therapy as an effective treatment option in refractory cases.
Keywords:
Psoriasis
Corticosteroid withdrawal
Cyclosporine
Ixekizumab
IL-17A inhibitor
Biologic therapy
Case Report
Open Access
Year: 2026
Case Report: The First Documented Case of Advanced Metastatic Dermatofi- brosarcoma Protuberans (DFSP) with Extensive Intrathoracic Dissemination and Mediastinal Shift in West Africa.
Asmell Ramos Cabrera, Hector O. Victoria Barzaga, Jennifer Shallop, Momodu Kabir Manneh, Syeda Qurat-ul-Ain Hasan, Al-Heri Bulus Mika Doctor
Abstract:
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive cutaneous malignancy with a low propensity for distant metastasis. When systemic dissemination occurs, it primarily targets the lungs, often secondary to a fibrosarcomatous transformation (FS-DFSP). We report the case of an 81-year-old Gambian male presenting with severe progressive dyspnea. He had a 14-year history of recurrent, disseminated cutaneous tumors across his limbs and torso, histologically confirmed as DFSP. Advanced thoracic imaging revealed a massive, space-occupying left intrathoracic mass causing complete lung collapse and a severe rightward mediastinal shift, alongside contralateral pulmonary nodules. To our knowledge, this represents the first documented report of advanced metastatic DFSP with extensive intrathoracic dissemination in West Africa. This case highlights the profound diagnostic challenges associated with the slow-growing nature of the tumor and the clinical difficulty less experienced physicians face in linking indolent dermatological conditions to internal organ affection. Furthermore, it underscores the logistical hurdles of managing complex soft-tissue sarcomas in resource-limited environments where specialized diagnostic validation and targeted therapies are unavailable.
Keywords:
Dermatofibrosarcoma protuberans
rare diseases
cancer
west Africa and Gambia.
Review Article
Open Access
Year: 2026
Does Clinical Semiology Still Matter? Evidence for the Primacy of History and Physical Examination in Modern Medicine, with a Focus on the Future Central Role of Internists
Emmanuel Andrès
Abstract:
Clinical semiology — the art and science of gathering and interpreting clinical signs and symptoms — has been practised since antiquity, yet its role in modern medicine is increasingly questioned in the era of sophisticated imaging, laboratory analytics, and artificial intelligence (AI). In this review, we present evidence that history taking and physical examination remain the cornerstone of the diagnostic process, accounting for approximately 76–82% of diagnoses in primary and secondary care settings. We examine the diagnostic accuracy and likelihood ratios of key clinical signs across major organ systems, discuss the consequences of declining bedside skills on diagnostic error rates, and explore how contemporary tools — including point-of-care ultrasonography (POCUS) and AI-assisted decision support — should complement rather than supplant semiological competence. We further highlight the pivotal and expanding role of internists, who, at the interface of primary and specialized care, are uniquely positioned to preserve, integrate, and advance clinical semiology in complex diagnostic reasoning. We conclude that semiology is irreplaceable, both as a diagnostic technology and as the foundation of the therapeutic physician–patient relationship, and propose a framework for its renaissance in 21st-century medical education and practice.
Keywords:
Semiology; Modern medicine; Evidence-based medicine; Physical examination; Medical history; Point-of-care ultrasonography; Artificial intelligence.
Research Article
Open Access
Year: 2026
The Cancer–Fever Myterious Relationship Explained. The New IR Quantum Technology Could Replace The Fever
Maria Kuman, PhD
Abstract:
A strange mysterious relationship was found between fever and cancer – people who had a very high fever were like immuned against cancer for 5 years. This remained unexplained for at least 20 years. I am explaining it now with the finding of Russian scientists that cancer is caused by the formation of crystals (with the shape of stacked coins) between the cells. This disconnects the cells and they start to multiply fast, just like they do in a cut wound to heal the wound fast. However, when in a wound the new cells are guided by the current of regrowth (that start at the cut) where to go, in the case of cancer there is nothing to guide the new cells where to go and they multiply senselessly, which is called malignancy. This article: 1/ explains the mysterious relationship cancer-fever - the high fever melts the crystals between the cells and restores the normal communication between the cells; 2/ offers to use IR lasers with nonlinear beams (because the field between the cells is nonlinear field (NEMF)) to do what the fever does – melt the crystals in the extracellular space.
Keywords:
Cancer; Explaining How Stress Causes Cancer; Congested Lymph System Also Causes Cancer; Fever Prevent Cancer; Explaining How Fever Prevent Cancer; Cure Of Cancer With Ir Laser
Editorial
Open Access
Year: 2026
The Effectiveness of Treatment Options for Localized Prostate Cancer-A Meta-Analysis of Cross-Sectional and Cohort Studies
Pius Omolewa
Case Report
Open Access
Year: 2026
Constipation and chronic prostatistis: aggravating factors, urinary retention and bacterial migration, role of the lymphatic system: direct – indirect traslocation hypotesys -Imaging can help?
Mauro Luisetto
Abstract:
Aim of this work is to verify the relationship ( anatomical, phisiological, pathological) between the constipation and the prostatitis , to evaluate literature related the way of bacterial diffusion or migration (Direct or indirect mechanism ). A case report is submitted and then a global conslusion is provided: in one of the first steps In the therapy of prostatitis must to be evaluated to resolve constipation to reduce also the pressure near the Prostate. The interconnession between the rectum with the prostate and the interelated lyphatic flux can explain why this simply procedure can alleviate the congestion.
Keywords:
Physiology
anatomy
pathology
urology
prostatitis
constipation
relationship
diffusion
migration of bacteria
Research Article
Open Access
Year: 2026
Rectal Prolapse is the Falling out of the Tissue of the Large Intestine
Siniša Franjić
Abstract:
Rectal prolapse refers to the displacement of the large intestine's tissue, specifically the last section of the digestive system, outside the body via the anal opening. In adults, the development of rectal prolapse occurs due to the deterioration of the anal sphincter or the supportive ligaments that maintain the rectum in its proper location. Such deterioration can result from aging, medical conditions, or infrequently, surgical damage. Increased intestinal contractions, prolonged use of laxatives, or acute diarrhea can also lead to prolapse.
Keywords:
Rectal Prolapse
Symptoms
Woman
Surgery
Health.