Musculoskeletal disorders (MSDs) are one of the common occupational disorders among CNG drivers but the prevalence rates are not well documented in our country. The objective of this study was to evaluate MSDs in terms of perception of pain experienced by the CNG drivers. A cross sectional carried among the 104 participants with MSDs was face to face interviewed for identifying associated risk factors and status of MSDs. The prevalence of musculoskeletal disorder among CNG drivers was 75.96%. One third participants are driving more than 200 km in everyday without use of back support more than 10 hours. More than half of participants had break and clutch are not in proper position. Statically association was found between clutch in proper position and musculoskeletal disorders. Among 104 participants; 51.0% break used in proper position followed by 49.0% was not break proper position. Statically association was found between break and exalter in proper position and musculoskeletal disorders. It is concluded that MSK disorders are more common among the CNG drivers and LBP are was the most common affected area. Musculoskeletal pain was related to the demography of the participants. More research is needed on musculoskeletal disorders among the CNG drivers with an emphasis on a larger sample size. Early identification and treatment will lead to the best possible outcome. Conservative management is the gold standard including physiotherapy, stabilization belts, nerve stimulation, pharmacological treatment, acupuncture, massage, relaxation, and yoga.