OA
Archives of Pediatrics and Child Health
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency In The Department Of Pediatrics At The Gabriel Toure Hospital
Authors: Diakite AA*, Traore F, Drame F, Sidibe Ln, Sacko K, Maiga B, Dicko F, Togo B, Sylla M
Publication Year: 2026
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common genetic enzymopathy worldwide. This study aimed to investigate the epidemiological and clinical profile of G6PD deficiency within the Department of Pediatrics at the Gabriel Touré University Hospital in Bamako, Mali. This prospective, descriptive study was conducted from December 1, 2024, to November 30, 2025. It included patients under 15 years of age who were hospitalized for anemia and jaundice, and had a laboratory-confirmed G6PD deficiency.
Twenty patients were included, representing a hospital frequency of 7.5%. Neonates aged 0-1 month constituted the majority of cases (75%). The sex ratio (M/F) was 5.6 (17 males, 3 females). Parental consanguinity was reported in 25% of cases. At admission, 90% of patients presented with jaundice (n = 18), and 55% had a history of blood transfusion. Indirect hyperbilirubinemia was the predominant laboratory finding. According to clinical staging, 70% of patients were classified as Stage A, 25% as Stage B, and 5% as Stage C. The mortality rate was 7.14%.