Objective: This study aims to evaluate the demographic characteristics, seasonal distribution, and the impact of the February 6, 2023, Kahramanmaraş earthquake on the frequency of applications for scabies (ICD-10: B86) at the Hatay Mustafa Kemal University Training and Research Hospital emergency department between 2015 and 2026.

Methods: Conducted as a retrospective cross-sectional study, 431 patients diagnosed with scabies in the emergency department were included. Case counts were examined in terms of gender, age group, application month, and year. To understand the earthquake’s impact, the average monthly application numbers for 2023, 2024, and 2025 were compared.

Results: Of the cases, 62.4% (n=269) were male and 37.6% (n=162) were female, with a male-to-female ratio of 1.66. The highest number of applications was observed in the 18–29 age group (26.0%), with a median age of 25 years (min: 1, max: 94). In the seasonal distribution, the highest rate was observed in autumn (28.1%), followed by spring (26.0%), summer (23.2%), and winter (22.7%). Annual case numbers showed a significant increase after the earthquake; 38 cases in 2023, 125 in 2024, and 216 in 2025. The average monthly application number increased from 3.2 in the earthquake year of 2023 to 18.0 in 2025, an approximately 5.7-fold increase.

Conclusion: It is considered that the number of scabies cases in the emergency department has continued to increase cumulatively following the February 6, 2023, earthquake, and this increase is associated with the ongoing socioeconomic and housing problems in the region. More comprehensive monitoring programs are recommended for disaster epidemiology and infectious skin diseases.