Yam stores relatively longer than most root crops and this attribute have gained it recognition as a food security crop in Nigeria. However, inadequate access and high cost of seed yams have prevented farmers from intensive sustainable production. New technologies to increase and make available quality seed yams to farmers can boost yam production, increase food security and improve farmers livelihoods. In this regard, construction and evaluation of modular aeroponics system for small scale seed yam production was carried out. The objective is to design and construct small modular aeroponics system for the production of seed yam also to evaluate the feasibility of generating seed yams from modular aeroponics system. Results of the technical evaluation of the modular aeroponics systems showed that all the installed components worked perfectly according to their specifications. The results of directly planted vines were impressive as plants and vines suspended in air continued growing normally with the development of new roots and shoots. Within 10 days, more than 50% of the vines produced roots and in week 3 after planting, 85–100% of the direct vine cuttings produced roots on the modular aeroponics system. Agronomic evaluation of vines planted on the modular aeroponics systems showed a progressive growth in all the parameters measured indicating the functionality of the system. The study demonstrates the potentials of modular aeroponics systems in the production of clean materials for small- medium scale seed yam production venture.